Our Publications

Publications
  1. Medeiros PJ, Pascetta SA, Kirsh SM, Al-Khazraji BK, Uniacke J, Expression of hypoxia inducible factor-dependent Neuropeptide Y Receptors Y1 and Y5 sensitizes hypoxic cells to NPY stimulation, Journal of Biological Chemistry (2022), doi: https://doi.org/10.1016/j.jbc.2022.101645.

  2. Ho JJD, Schatz JH, Uniacke J, Lee S. Jekyll and Hyde: Activating the Hypoxic Translational Machinery. Trends Biochem Sci. 2020 Dec 9:S0968-0004(20)30277-2. doi: 10.1016/j.tibs.2020.11.006. Epub ahead of print. PMID: 33309326.

  3. Jewer M, Lee L, Leibovitch M, Zhang G, Liu J, Findlay SD, Vincent KM, Tandoc K, Dieters-Castator D, Quail DF, Dutta I, Coatham M, Xu Z, Puri A, Guan BJ, Hatzoglou M, Brumwell A, Uniacke J, Patsis C, Koromilas A, Schueler J, Siegers GM, Topisirovic I, Postovit LM. Translational control of breast cancer plasticity. Nat Commun. 2020 May 19;11(1):2498. doi: 10.1038/s41467-020-16352-z.PMID: 32427827; PMCID: PMC7237473.

  4. Evagelou SL, Bebenek O, Specker EJ, Uniacke J. DEAD Box Protein Family Member DDX28 Is a Negative Regulator of Hypoxia-Inducible Factor 2α- and Eukaryotic Initiation Factor 4E2-Directed Hypoxic Translation. Mol Cell Biol. 2020 Feb 27;40(6):e00610-19. doi: 10.1128/MCB.00610-19. PMID: 31907278; PMCID: PMC7048264.

  5. Brumwell A, Fell L, Obress L, Uniacke J. Hypoxia influences polysome distribution of human ribosomal protein S12 and alternative splicing of ribosomal protein mRNAs. RNA. 2020 Mar;26(3):361-371. doi:10.1261/rna.070318.119. Epub 2020 Jan 7. PMID: 31911497; PMCID: PMC7025504.

  6. Timpano S, Guild BD, Specker EJ, Melanson G, Medeiros PJ, Sproul SLJ, Uniacke J. Physioxic human cell culture improves viability, metabolism, and mitochondrial morphology while reducing DNA damage. FASEB J. 2019 Apr;33(4):5716-5728. doi: 10.1096/fj.201802279R. Epub 2019 Jan 16. PMID:30649960.

  7. Zhan Y, Marchand CH, Maes A, Mauries A, Sun Y, Dhaliwal JS, Uniacke J, Arragain S, Jiang H, Gold ND, Martin VJJ, Lemaire SD, Zerges W. Pyrenoid functions revealed by proteomics in Chlamydomonas reinhardtii. PLoS One. 2018 Feb 26;13(2):e0185039. doi: 10.1371/journal.pone.0185039. PMID: 29481573; PMCID: PMC5826530.

  8. Kelly NJ, Varga JFA, Specker EJ, Romeo CM, Coomber BL, Uniacke J. Hypoxia activates cadherin-22 synthesis via eIF4E2 to drive cancer cell migration, invasion and adhesion. Oncogene. 2018 Feb 1;37(5):651-662. doi: 10.1038/onc.2017.372. Epub 2017 Oct 9. PMID: 28991229; PMCID: PMC5770212.

  9. Melanson G, Timpano S, Uniacke J. The eIF4E2-Directed Hypoxic Cap-Dependent Translation Machinery Reveals Novel Therapeutic Potential for Cancer Treatment. Oxid Med Cell Longev. 2017;2017:6098107. doi: 10.1155/2017/6098107. Epub 2017 Nov 26. PMID: 29317983; PMCID: PMC5727761.

  10. Brasher MI, Martynowicz DM, Grafinger OR, Hucik A, Shanks-Skinner E, Uniacke J, Coppolino MG. Interaction of Munc18c and syntaxin4 facilitates invadopodium formation and extracellular matrix invasion of tumor cells. J Biol Chem. 2017 Sep 29;292(39):16199-16210. doi: 10.1074/jbc.M117.807438. Epub 2017 Aug 10. PMID: 28798239; PMCID: PMC5625050.

  11. Timpano S, Melanson G, Evagelou SL, Guild BD, Specker EJ, Uniacke J. Analysis of Cap-binding Proteins in Human Cells Exposed to Physiological Oxygen Conditions. J Vis Exp. 2016 Dec 28;(118):55112. doi: 10.3791/55112. PMID: 28060265; PMCID: PMC5226629.

  12. Timpano S, Uniacke J. Human Cells Cultured under Physiological Oxygen Utilize Two Cap-binding Proteins to recruit Distinct mRNAs for Translation. J Biol Chem. 2016 May 13;291(20):10772-82. doi: 10.1074/jbc.M116.717363. Epub 2016 Mar 21. PMID: 27002144; PMCID: PMC4865923.

  13. Ho JJD, Wang M, Audas TE, Kwon D, Carlsson SK, Timpano S, Evagelou SL, Brothers S, Gonzalgo ML, Krieger JR, Chen S, Uniacke J, Lee S. Systemic Reprogramming of Translation Efficiencies on Oxygen Stimulus. Cell Rep. 2016 Feb 16;14(6):1293-1300. doi: 10.1016/j.celrep.2016.01.036. Epub 2016 Feb 4. PMID:26854219; PMCID: PMC4758860.

  14. Zhan Y, Dhaliwal JS, Adjibade P, Uniacke J, Mazroui R, Zerges W. Localized control of oxidized RNA. J Cell Sci. 2015 Nov 15;128(22):4210-9. doi: 10.1242/jcs.175232. Epub 2015 Oct 8. PMID: 26449969.

  15. Uniacke J, Perera JK, Lachance G, Francisco CB, Lee S. Cancer cells exploit eIF4E2-directed synthesis of hypoxia response proteins to drive tumor progression. Cancer Res. 2014 Mar 1;74(5):1379-89. doi: 10.1158/0008-5472.CAN-13-2278. Epub 2014 Jan 9. PMID: 24408918.

  16. Lachance G, Uniacke J, Audas TE, Holterman CE, Franovic A, Payette J, Lee S. DNMT3a epigenetic program regulates the HIF-2α oxygen-sensing pathway and the cellular response to hypoxia. Proc Natl Acad Sci U S A. 2014 May 27;111(21):7783-8. doi: 10.1073/pnas.1322909111. Epub 2014 May 9. PMID: 24817692; PMCID: PMC4040594.

  17. Jacob MD, Audas TE, Uniacke J, Trinkle-Mulcahy L, Lee S. Environmental cues induce a long noncoding RNA-dependent remodeling of the nucleolus. Mol Biol Cell. 2013 Sep;24(18):2943-53. doi: 10.1091/mbc.E13-04-0223. Epub 2013 Jul 31. PMID: 23904269; PMCID: PMC3771955.

  18. Uniacke J, Holterman CE, Lachance G, Franovic A, Jacob MD, Fabian MR, Payette J, Holcik M, Pause A, Lee S. An oxygen-regulated switch in the protein synthesis machinery. Nature. 2012 May 6;486(7401):126-9. doi: 10.1038/nature11055. PMID: 22678294; PMCID: PMC4974072.

  19. Uniacke J, Colón-Ramos D, Zerges W. FISH and immunofluorescence staining in Chlamydomonas. Methods Mol Biol. 2011;714:15-29. doi: 10.1007/978-1-61779-005-8_2. PMID: 21431732.

  20. Uniacke J, Zerges W. Chloroplast protein targeting involves localized translation in Chlamydomonas. Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1439-44. doi: 10.1073/pnas.0811268106. Epub 2009 Jan 21. PMID: 19164529; PMCID: PMC2629442.

  21. Uniacke J, Zerges W. Stress induces the assembly of RNA granules in the chloroplast of Chlamydomonas reinhardtii. J Cell Biol. 2008 Aug 25;182(4):641-6. doi: 10.1083/jcb.200805125. Epub 2008 Aug 18. PMID: 18710928; PMCID: PMC2518703.

  22. Uniacke J, Zerges W. Photosystem II assembly and repair are differentially localized in Chlamydomonas. Plant Cell. 2007 Nov;19(11):3640-54. doi: 10.1105/tpc.107.054882. Epub 2007 Nov 30. PMID: 18055604; PMCID: PMC2174875.